Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists

A series of 2-substituted 4-(trifluoromethyl)benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides were investigated for hTRPV1 antagonism. The analysis indicated that the phenyl C-region derivatives exhibited better antagonism than those of the corresponding pyridine surroga...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Ann, Jihyae, Jung, Aeran, Kim, Mi-Yeon, Kim, Hyuk-Min, Ryu, HyungChul, Kim, Sunjoo, Kang, Dong Wook, Hong, Sunhye, Cui, Minghua, Choi, Sun, Blumberg, Peter M., Frank-Foltyn, Robert, Bahrenberg, Gregor, Stockhausen, Hannelore, Christoph, Thomas, Lee, Jeewoo
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959537/
https://ncbi.nlm.nih.gov/pubmed/26474664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.10.001
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados