2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists

A series of 2-sulfonamidopyridine C-region derivatives of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamide were investigated as hTRPV1 ligands. Systematic modification on the 2-sulfonamido group provided highly potent TRPV1 antagonists. The N-benzyl phenylsulfonamide derivatives 12 and 23 in partic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Ann, Jihyae, Ki, Yooran, Yoon, Suyoung, Kim, Myeong Seop, Lee, Jung-Un, Kim, Changhoon, Lee, Sunho, Jung, Aeran, Baek, Jisoo, Hong, Sunhye, Choi, Sun, Pearce, Larry V., Esch, Timothy E., Turcios, Noe A., Lewin, Nancy E., Ogunjirin, Adebowale E., Herold, Brienna K. A., McCall, Anna K., Blumberg, Peter M., Lee, Jeewoo
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957252/
https://ncbi.nlm.nih.gov/pubmed/26860926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.01.051
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados