2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists

A series of 2-sulfonamidopyridine C-region derivatives of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamide were investigated as hTRPV1 ligands. Systematic modification on the 2-sulfonamido group provided highly potent TRPV1 antagonists. The N-benzyl phenylsulfonamide derivatives 12 and 23 in partic...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Ann, Jihyae, Ki, Yooran, Yoon, Suyoung, Kim, Myeong Seop, Lee, Jung-Un, Kim, Changhoon, Lee, Sunho, Jung, Aeran, Baek, Jisoo, Hong, Sunhye, Choi, Sun, Pearce, Larry V., Esch, Timothy E., Turcios, Noe A., Lewin, Nancy E., Ogunjirin, Adebowale E., Herold, Brienna K. A., McCall, Anna K., Blumberg, Peter M., Lee, Jeewoo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957252/
https://ncbi.nlm.nih.gov/pubmed/26860926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.01.051
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