MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota

Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation (BMT). Here, we examined the mechanisms that initiate GVHD, including the relevant antigen presenting cells. MHC-class-II was expressed on in...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S, Henden, Andrea S, Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D, Robb, Renee J, Zhang, Ping, Blazar, Bruce R, Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D, Degli-Esposti, Mariapia A, Hill, Geoffrey R
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959419/
https://ncbi.nlm.nih.gov/pubmed/31542340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.08.011
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