Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Donor T-cell–derived interleukin-17A (IL-17A) can mediate late immunopathology in graft-versus-host disease (GVHD), however protective roles remain unclear. Using multiple cytokine and cytokine receptor subunit knockout mice, we demonstrate that stem cell transplant recipients lacking the ability to...

詳細記述

保存先:
書誌詳細
出版年:Blood
主要な著者: Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A., Hugenholtz, Philip, Hill, Geoffrey R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2017
主題:
Transplantation
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391622/
https://ncbi.nlm.nih.gov/pubmed/28137828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-732628
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