Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Donor T-cell–derived interleukin-17A (IL-17A) can mediate late immunopathology in graft-versus-host disease (GVHD), however protective roles remain unclear. Using multiple cytokine and cytokine receptor subunit knockout mice, we demonstrate that stem cell transplant recipients lacking the ability to...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A., Hugenholtz, Philip, Hill, Geoffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391622/
https://ncbi.nlm.nih.gov/pubmed/28137828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-732628
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