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Hypoxia-inducible factor (HIF)-1alpha knockout accelerates intervertebral disc degeneration in mice

Introduction: The abnormality of nucleus pulposus (NP) plays a critical role in intervertebral disc (IVD) degeneration, in which NP cells show apoptosis and fibrosis, leading to the ability of the disc to transfer and distribute loads between the vertebrae is decreased. Considering that hypoxia indu...

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Detalhes bibliográficos
Publicado no:Int J Clin Exp Pathol
Main Authors: Meng, Xiangchao, Zhuang, Lingling, Wang, Jun, Liu, Zhuochao, Wang, You, Xiao, Dechang, Zhang, Xingkai
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957989/
https://ncbi.nlm.nih.gov/pubmed/31938140
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