Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging

Approximately 40% of people under 30 and over 90% of people 55 or older suffer from moderate-to-severe levels of degenerative intervertebral disc (IVD) disease in their lumbar spines. Surgical treatments are sometimes effective; however, the treatment of back pain related to IVD degeneration is stil...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Ohnishi, Takashi, Yamada, Katsuhisa, Iwasaki, Koji, Tsujimoto, Takeru, Higashi, Hideaki, Kimura, Taichi, Iwasaki, Norimasa, Sudo, Hideki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920379/
https://ncbi.nlm.nih.gov/pubmed/31852919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55709-3
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