Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant

Spinal muscular atrophy (SMA) is a devastating motor neuron disorder caused by mutations in the survival motor neuron (SMN) gene. It remains unclear how SMN deficiency leads to the loss of motor neurons. By screening Schizosaccharomyces pombe, we found that the growth defect of an SMN mutant can be...

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Publicat a:iScience
Autors principals: Antoine, Marie, Patrick, Kristin L., Soret, Johann, Duc, Pauline, Rage, Florence, Cacciottolo, Rebecca, Nissen, Kelly E., Cauchi, Ruben J., Krogan, Nevan J., Guthrie, Christine, Gachet, Yannick, Bordonné, Rémy
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957872/
https://ncbi.nlm.nih.gov/pubmed/31927482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.100809
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