Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant

Spinal muscular atrophy (SMA) is a devastating motor neuron disorder caused by mutations in the survival motor neuron (SMN) gene. It remains unclear how SMN deficiency leads to the loss of motor neurons. By screening Schizosaccharomyces pombe, we found that the growth defect of an SMN mutant can be...

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Foilsithe in:iScience
Main Authors: Antoine, Marie, Patrick, Kristin L., Soret, Johann, Duc, Pauline, Rage, Florence, Cacciottolo, Rebecca, Nissen, Kelly E., Cauchi, Ruben J., Krogan, Nevan J., Guthrie, Christine, Gachet, Yannick, Bordonné, Rémy
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957872/
https://ncbi.nlm.nih.gov/pubmed/31927482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.100809
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