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Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant
Spinal muscular atrophy (SMA) is a devastating motor neuron disorder caused by mutations in the survival motor neuron (SMN) gene. It remains unclear how SMN deficiency leads to the loss of motor neurons. By screening Schizosaccharomyces pombe, we found that the growth defect of an SMN mutant can be...
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| Pubblicato in: | iScience |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6957872/ https://ncbi.nlm.nih.gov/pubmed/31927482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.100809 |
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