טוען...
Endogenous MicroRNA Competition as a Mechanism of shRNA-Induced Cardiotoxicity
Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disrupt the processing of endogenous microRNAs (miRNAs) and lead to toxicity. Here, we sought to understand the effect that excessive shRNAs have on muscl...
שמור ב:
| הוצא לאור ב: | Mol Ther Nucleic Acids |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society of Gene & Cell Therapy
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6957822/ https://ncbi.nlm.nih.gov/pubmed/31927330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.12.007 |
| תגים: |
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