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Endogenous MicroRNA Competition as a Mechanism of shRNA-Induced Cardiotoxicity
Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disrupt the processing of endogenous microRNAs (miRNAs) and lead to toxicity. Here, we sought to understand the effect that excessive shRNAs have on muscl...
Gespeichert in:
| Veröffentlicht in: | Mol Ther Nucleic Acids |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Gene & Cell Therapy
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6957822/ https://ncbi.nlm.nih.gov/pubmed/31927330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.12.007 |
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