Early lethality of shRNA-transgenic pigs due to saturation of microRNA pathways

RNA interference (RNAi) is considered as a potential modality for clinical treatment and anti-virus animal breeding. Here, we investigate the feasibility of inhibiting classical swine fever virus (CSFV) replication by short hairpin RNA (shRNA) in vitro and in vivo. We generate four different shRNA-p...

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Detalhes bibliográficos
Main Authors: Dai, Zhen, Wu, Rong, Zhao, Yi-cheng, Wang, Kan-kan, Huang, Yong-ye, Yang, Xin, Xie, Zi-cong, Tu, Chang-chun, Ouyang, Hong-sheng, Wang, Tie-dong, Pang, Da-xin
Formato: Artigo
Idioma:Inglês
Publicado em: Zhejiang University Press 2014
Assuntos:
Genetics and Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076603/
https://ncbi.nlm.nih.gov/pubmed/24793764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.B1400001
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