Early lethality of shRNA-transgenic pigs due to saturation of microRNA pathways

RNA interference (RNAi) is considered as a potential modality for clinical treatment and anti-virus animal breeding. Here, we investigate the feasibility of inhibiting classical swine fever virus (CSFV) replication by short hairpin RNA (shRNA) in vitro and in vivo. We generate four different shRNA-p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dai, Zhen, Wu, Rong, Zhao, Yi-cheng, Wang, Kan-kan, Huang, Yong-ye, Yang, Xin, Xie, Zi-cong, Tu, Chang-chun, Ouyang, Hong-sheng, Wang, Tie-dong, Pang, Da-xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Zhejiang University Press 2014
Schlagworte:
Genetics and Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076603/
https://ncbi.nlm.nih.gov/pubmed/24793764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.B1400001
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