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Endogenous MicroRNA Competition as a Mechanism of shRNA-Induced Cardiotoxicity

Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disrupt the processing of endogenous microRNAs (miRNAs) and lead to toxicity. Here, we sought to understand the effect that excessive shRNAs have on muscl...

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Библиографические подробности
Опубликовано в: :Mol Ther Nucleic Acids
Главные авторы: Course, Meredith M., Gudsnuk, Kathryn, Desai, Nitin, Chamberlain, Joel R., Valdmanis, Paul N.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957822/
https://ncbi.nlm.nih.gov/pubmed/31927330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.12.007
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