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Endogenous MicroRNA Competition as a Mechanism of shRNA-Induced Cardiotoxicity

Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disrupt the processing of endogenous microRNAs (miRNAs) and lead to toxicity. Here, we sought to understand the effect that excessive shRNAs have on muscl...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Mol Ther Nucleic Acids
मुख्य लेखकों: Course, Meredith M., Gudsnuk, Kathryn, Desai, Nitin, Chamberlain, Joel R., Valdmanis, Paul N.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Gene & Cell Therapy 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957822/
https://ncbi.nlm.nih.gov/pubmed/31927330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.12.007
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