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Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones)

DAG-lactones afford a synthetically accessible, high affinity platform for probing structure activity relationships at the C1 regulatory domain of protein kinase C (PKC). Given the central role of PKC isoforms in cellular signaling, along with their differential biological activities, a critical obj...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Eur J Med Chem
Egile Nagusiak: Ann, Jihyae, Yoon, Suyoung, Baek, Jisoo, Kim, Da Hye, Lewin, Nancy E., Hill, Colin S., Blumberg, Peter M., Lee, Jeewoo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957255/
https://ncbi.nlm.nih.gov/pubmed/25437619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.11.025
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