Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation

Interleukin 15 (IL-15) is an essential cytokine for the survival and proliferation of natural killer (NK) cells. IL-15 activates signaling by the β and common γ (γ(c)) chain heterodimer of the IL-2 receptor through trans-presentation by cells expressing IL-15 bound to the α chain of the IL-15 recept...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Anton, Olga M., Peterson, Mary E., Hollander, Michael J., Dorward, David W., Arora, Gunjan, Traba, Javier, Rajagopalan, Sumati, Snapp, Erik L., Garcia, K. Christopher, Waldmann, Thomas A., Long, Eric O.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955382/
https://ncbi.nlm.nih.gov/pubmed/31871169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911678117
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