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Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities
To understand the molecular evolution of functional diversity in protein families, we comprehensively investigated the consequences of all possible mutation combinations separating two peptide‐binding domains with highly divergent specificities. We analyzed the Erbin PDZ domain (Erbin‐PDZ), which ex...
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| Publicado en: | Protein Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley & Sons, Inc.
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6954693/ https://ncbi.nlm.nih.gov/pubmed/31654425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3759 |
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