Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

The human proteome contains a plethora of short linear motifs (SLiMs) that serve as binding interfaces for modular protein domains. Such interactions are crucial for signaling and other cellular processes, but are difficult to detect because of their low to moderate affinities. Here we developed a d...

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Detalhes bibliográficos
Main Authors: Ivarsson, Ylva, Arnold, Roland, McLaughlin, Megan, Nim, Satra, Joshi, Rakesh, Ray, Debashish, Liu, Bernard, Teyra, Joan, Pawson, Tony, Moffat, Jason, Li, Shawn Shun-Cheng, Sidhu, Sachdev S., Kim, Philip M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932933/
https://ncbi.nlm.nih.gov/pubmed/24550280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312296111
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