Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

The human proteome contains a plethora of short linear motifs (SLiMs) that serve as binding interfaces for modular protein domains. Such interactions are crucial for signaling and other cellular processes, but are difficult to detect because of their low to moderate affinities. Here we developed a d...

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Autori principali: Ivarsson, Ylva, Arnold, Roland, McLaughlin, Megan, Nim, Satra, Joshi, Rakesh, Ray, Debashish, Liu, Bernard, Teyra, Joan, Pawson, Tony, Moffat, Jason, Li, Shawn Shun-Cheng, Sidhu, Sachdev S., Kim, Philip M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932933/
https://ncbi.nlm.nih.gov/pubmed/24550280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312296111
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