Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA

Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticosterone presentation reveals MR and GR co-occupy DNA...

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Bibliographic Details
Published in:PLoS One
Main Authors: Pooley, John R., Rivers, Caroline A., Kilcooley, Michael T., Paul, Susana N., Cavga, Ayse Derya, Kershaw, Yvonne M., Muratcioglu, Serena, Gursoy, Attila, Keskin, Ozlem, Lightman, Stafford L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953809/
https://ncbi.nlm.nih.gov/pubmed/31923266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227520
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