Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids

Mammalian target of rapamycin complex 1 (mTORC1) promotes cell growth and proliferation in response to nutrients and growth factors. Amino acids induce lysosomal translocation of mTORC1 via the Rag GTPases. Growth factors activate Ras homolog enriched in brain (Rheb), which in turn activates mTORC1...

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Publicado en:J Biol Chem
Autores principales: Frias, Maria A., Mukhopadhyay, Suman, Lehman, Elyssa, Walasek, Aleksandra, Utter, Matthew, Menon, Deepak, Foster, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952608/
https://ncbi.nlm.nih.gov/pubmed/31767684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010892
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