Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes

Insulin action in adipose tissue is crucial for whole-body glucose homeostasis, with insulin resistance being a major risk factor for metabolic diseases such as type 2 diabetes. Recent studies have proposed mitochondrial oxidants as a unifying driver of adipose insulin resistance, serving as a signa...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Krycer, James R., Elkington, Sarah D., Diaz-Vegas, Alexis, Cooke, Kristen C., Burchfield, James G., Fisher-Wellman, Kelsey H., Cooney, Gregory J., Fazakerley, Daniel J., James, David E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Bioenergetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952605/
https://ncbi.nlm.nih.gov/pubmed/31744882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011695
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