Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes

The Ser/Thr protein kinase Akt regulates essential biological processes such as cell survival, growth, and metabolism. Upon growth factor stimulation, Akt is phosphorylated at Ser(474); however, how this phosphorylation contributes to Akt activation remains controversial. Previous studies, which ind...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Kearney, Alison L., Cooke, Kristen C., Norris, Dougall M., Zadoorian, Armella, Krycer, James R., Fazakerley, Daniel J., Burchfield, James G., James, David E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851323/
https://ncbi.nlm.nih.gov/pubmed/31548312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010036
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