Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes

Akt plays a major role in insulin regulation of metabolism in muscle, fat, and liver. Here, we show that in 3T3-L1 adipocytes, Akt operates optimally over a limited dynamic range. This indicates that Akt is a highly sensitive amplification step in the pathway. With robust insulin stimulation, substa...

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Bibliografiske detaljer
Main Authors: Tan, Shi-Xiong, Ng, Yvonne, Meoli, Christopher C., Kumar, Ansu, Khoo, Poh-Sim, Fazakerley, Daniel J., Junutula, Jagath R., Vali, Shireen, James, David E., Stöckli, Jacqueline
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307283/
https://ncbi.nlm.nih.gov/pubmed/22207758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318238
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