Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes

Akt plays a major role in insulin regulation of metabolism in muscle, fat, and liver. Here, we show that in 3T3-L1 adipocytes, Akt operates optimally over a limited dynamic range. This indicates that Akt is a highly sensitive amplification step in the pathway. With robust insulin stimulation, substa...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tan, Shi-Xiong, Ng, Yvonne, Meoli, Christopher C., Kumar, Ansu, Khoo, Poh-Sim, Fazakerley, Daniel J., Junutula, Jagath R., Vali, Shireen, James, David E., Stöckli, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307283/
https://ncbi.nlm.nih.gov/pubmed/22207758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318238
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados