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Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment

The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to tumors. T-cell exhaustion and senescence induced by malignant tumors are two important dysfunctional states that co...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Zhao, Yangjing, Shao, Qixiang, Peng, Guangyong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952436/
https://ncbi.nlm.nih.gov/pubmed/31853000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0344-8
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