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Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy

The functional state of the preexisting T cells in the tumor microenvironment is a key determinant for effective antitumor immunity and immunotherapy. Increasing evidence suggests that immunosenescence is an important state of T cell dysfunction that is distinct from exhaustion, a key strategy used...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Liu, Xia, Hoft, Daniel F., Peng, Guangyong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269563/
https://ncbi.nlm.nih.gov/pubmed/32118585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133679
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