Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are elevated in the circulation of patients with glioblastoma (GBM), present in tumor tissue, and associated with poor prognosis. While low-dose chemotherapy reduces MDSCs in preclinical models, the use of this strategy to reduce MDSCs in GBM pati...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Peereboom, David M., Alban, Tyler J., Grabowski, Matthew M., Alvarado, Alvaro G., Otvos, Balint, Bayik, Defne, Roversi, Gustavo, McGraw, Mary, Huang, Pengjing, Mohammadi, Alireza M., Kornblum, Harley I., Radivoyevitch, Tomas, Ahluwalia, Manmeet S., Vogelbaum, Michael A., Lathia, Justin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948860/
https://ncbi.nlm.nih.gov/pubmed/31600167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130748
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