Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are elevated in the circulation of patients with glioblastoma (GBM), present in tumor tissue, and associated with poor prognosis. While low-dose chemotherapy reduces MDSCs in preclinical models, the use of this strategy to reduce MDSCs in GBM pati...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Peereboom, David M., Alban, Tyler J., Grabowski, Matthew M., Alvarado, Alvaro G., Otvos, Balint, Bayik, Defne, Roversi, Gustavo, McGraw, Mary, Huang, Pengjing, Mohammadi, Alireza M., Kornblum, Harley I., Radivoyevitch, Tomas, Ahluwalia, Manmeet S., Vogelbaum, Michael A., Lathia, Justin D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Clinical Medicine
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948860/
https://ncbi.nlm.nih.gov/pubmed/31600167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130748
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