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2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy

In addition to its well-known beneficial effects for the treatment of several types of cancer, PD-1 blockade has shown encouraging results in preclinical models of sepsis and in a recent clinical trial in sepsis. Because cancer is the most common comorbidity in septic patients, here we aimed to dete...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Chen, Ching-wen, Xue, Ming, Zhang, Wenxiao, Xie, Jianfeng, Coopersmith, Craig M., Ford, Mandy L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948854/
https://ncbi.nlm.nih.gov/pubmed/31723059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127867
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