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CD28 agonism improves survival in immunologically experienced septic mice via IL-10 released by Foxp3(+) regulatory T cells
Immune dysregulation during sepsis is mediated by an imbalance of T cell costimulatory and coinhibitory signaling. CD28 is downregulated during sepsis and is significantly altered on memory vs. naïve T cells. Thus, in order to study the role of CD28 during sepsis in a more physiologically relevant c...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7725929/ https://ncbi.nlm.nih.gov/pubmed/33158954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000595 |
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