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CD45 functions as a signaling gatekeeper in T cells
T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell receptor (TCR) complex. CD45 activates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicat...
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| Veröffentlicht in: | Sci Signal |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6948007/ https://ncbi.nlm.nih.gov/pubmed/31641081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaw8151 |
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