CD45 functions as a signaling gatekeeper in T cells

T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell receptor (TCR) complex. CD45 activates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicat...

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Udgivet i:Sci Signal
Main Authors: Courtney, Adam H., Shvets, Alexey A., Lu, Wen, Griffante, Gloria, Mollenauer, Marianne, Horkova, Veronika, Lo, Wan-Lin, Yu, Steven, Stepanek, Ondrej, Chakraborty, Arup K., Weiss, Arthur
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948007/
https://ncbi.nlm.nih.gov/pubmed/31641081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaw8151
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