Loading...
2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition
p97 is a hexameric AAA+ adenosine triphosphatase (ATPase) that is an attractive target for cancer drug development. We report cryo–electron microscopy (cryo-EM) structures for adenosine diphosphate (ADP)–bound, full-length, hexameric wild-type p97 in the presence and absence of an allosteric inhibit...
Na minha lista:
| Udgivet i: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6946184/ https://ncbi.nlm.nih.gov/pubmed/26822609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad7974 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|