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Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway
[Image: see text] A high-throughput screen to discover inhibitors of p97 ATPase activity identified an indole amide that bound to an allosteric site of the protein. Medicinal chemistry optimization led to improvements in potency and solubility. Indole amide 3 represents a novel uncompetitive inhibit...
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| Pubblicato in: | ACS Med Chem Lett |
|---|---|
| Autori principali: | , , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2015
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4753542/ https://ncbi.nlm.nih.gov/pubmed/26985295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00396 |
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