Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway

[Image: see text] A high-throughput screen to discover inhibitors of p97 ATPase activity identified an indole amide that bound to an allosteric site of the protein. Medicinal chemistry optimization led to improvements in potency and solubility. Indole amide 3 represents a novel uncompetitive inhibit...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:ACS Med Chem Lett
Autori principali: Alverez, Celeste, Bulfer, Stacie L., Chakrasali, Ramappa, Chimenti, Michael. S., Deshaies, Raymond J., Green, Neal, Kelly, Mark, LaPorte, Matthew G., Lewis, Taber S., Liang, Mary, Moore, William J., Neitz, R. Jeffrey, Peshkov, Vsevolod A., Walters, Michael A., Zhang, Feng, Arkin, Michelle R., Wipf, Peter, Huryn, Donna M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2015
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753542/
https://ncbi.nlm.nih.gov/pubmed/26985295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00396
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi