Llwytho...
Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway
[Image: see text] A high-throughput screen to discover inhibitors of p97 ATPase activity identified an indole amide that bound to an allosteric site of the protein. Medicinal chemistry optimization led to improvements in potency and solubility. Indole amide 3 represents a novel uncompetitive inhibit...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | ACS Med Chem Lett |
|---|---|
| Prif Awduron: | , , , , , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical
Society
2015
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4753542/ https://ncbi.nlm.nih.gov/pubmed/26985295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00396 |
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