Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97

[Image: see text] Exploratory SAR studies of a new phenyl indole chemotype for p97 inhibition revealed C-5 indole substituent effects in the ADPGlo assay that did not fully correlate with either electronic or steric factors. A focused series of methoxy-, trifluoromethoxy-, methyl-, trifluoromethyl-,...

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Publicado en:ACS Med Chem Lett
Main Authors: Alverez, Celeste, Arkin, Michelle R., Bulfer, Stacie L., Colombo, Raffaele, Kovaliov, Marina, LaPorte, Matthew G., Lim, Chaemin, Liang, Mary, Moore, William J., Neitz, R. Jeffrey, Yan, Yongzhao, Yue, Zhizhou, Huryn, Donna M., Wipf, Peter
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677369/
https://ncbi.nlm.nih.gov/pubmed/26713109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00364
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