Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97

[Image: see text] Exploratory SAR studies of a new phenyl indole chemotype for p97 inhibition revealed C-5 indole substituent effects in the ADPGlo assay that did not fully correlate with either electronic or steric factors. A focused series of methoxy-, trifluoromethoxy-, methyl-, trifluoromethyl-,...

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Udgivet i:ACS Med Chem Lett
Main Authors: Alverez, Celeste, Arkin, Michelle R., Bulfer, Stacie L., Colombo, Raffaele, Kovaliov, Marina, LaPorte, Matthew G., Lim, Chaemin, Liang, Mary, Moore, William J., Neitz, R. Jeffrey, Yan, Yongzhao, Yue, Zhizhou, Huryn, Donna M., Wipf, Peter
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677369/
https://ncbi.nlm.nih.gov/pubmed/26713109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00364
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