A novel strategy to block mitotic progression for targeted therapy

BACKGROUND: Blockade of mitotic progression is an ideal approach to induce mitotic catastrophe that suppresses cancer cell expansion. Cdc20 is a critical mitotic factor governing anaphase initiation and the exit from mitosis through recruiting substrates to APC/C for degradation. Results from recent...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Chi, Junlong (Jack), Li, Hongchun, Zhou, Zhuan, Izquierdo-Ferrer, Javier, Xue, Yifan, Wavelet, Cindy M., Schiltz, Gary E., Zhang, Bin, Cristofanilli, Massimo, Lu, Xinghua, Bahar, Ivet, Wan, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945239/
https://ncbi.nlm.nih.gov/pubmed/31669221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.013
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