Pharmacological suppression of B7-H4 glycosylation restores antitumor immunity in immune-cold breast cancers

Despite widespread utilization of immunotherapy, treating immune-cold tumors has proven to be a challenge. Here, we report that expression of the immune checkpoint molecule B7-H4 is prevalent among immune-cold triple negative breast cancers, where its expression inversely correlates with that of PD-...

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Bibliografiske detaljer
Udgivet i:Cancer Discov
Main Authors: Song, Xinxin, Zhou, Zhuan, Li, Hongchun, Xue, Yifan, Lu, Xinghua, Bahar, Ivet, Kepp, Oliver, Hung, Mien-Chie, Kroemer, Guido, Wan, Yong
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710601/
https://ncbi.nlm.nih.gov/pubmed/32938586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0402
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