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A novel strategy to block mitotic progression for targeted therapy
BACKGROUND: Blockade of mitotic progression is an ideal approach to induce mitotic catastrophe that suppresses cancer cell expansion. Cdc20 is a critical mitotic factor governing anaphase initiation and the exit from mitosis through recruiting substrates to APC/C for degradation. Results from recent...
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| Veröffentlicht in: | EBioMedicine |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6945239/ https://ncbi.nlm.nih.gov/pubmed/31669221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.013 |
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