c-Jun overexpression in CAR T cells induces exhaustion resistance

CAR T cells mediate antitumor effects in a small subset of cancer patients(1–3), but dysfunction due to T cell exhaustion is an important barrier to progress(4–6). To investigate the biology of exhaustion in human T cells expressing CAR receptors, we used a model system employing a tonically signali...

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Gepubliceerd in:Nature
Hoofdauteurs: Lynn, Rachel C., Weber, Evan W., Sotillo, Elena, Gennert, David, Xu, Peng, Good, Zinaida, Anbunathan, Hima, Lattin, John, Jones, Robert, Tieu, Victor, Nagaraja, Surya, Granja, Jeffrey, DeBourcy, Charles, Majzner, Robbie, Satpathy, Ansuman T., Quake, Stephen R., Monje, Michelle, Chang, Howard, Mackall, Crystal L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944329/
https://ncbi.nlm.nih.gov/pubmed/31802004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1805-z
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