c-Jun overexpression in CAR T cells induces exhaustion resistance

CAR T cells mediate antitumor effects in a small subset of cancer patients(1–3), but dysfunction due to T cell exhaustion is an important barrier to progress(4–6). To investigate the biology of exhaustion in human T cells expressing CAR receptors, we used a model system employing a tonically signali...

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Udgivet i:Nature
Main Authors: Lynn, Rachel C., Weber, Evan W., Sotillo, Elena, Gennert, David, Xu, Peng, Good, Zinaida, Anbunathan, Hima, Lattin, John, Jones, Robert, Tieu, Victor, Nagaraja, Surya, Granja, Jeffrey, DeBourcy, Charles, Majzner, Robbie, Satpathy, Ansuman T., Quake, Stephen R., Monje, Michelle, Chang, Howard, Mackall, Crystal L.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944329/
https://ncbi.nlm.nih.gov/pubmed/31802004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1805-z
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