c-Jun overexpression in CAR T cells induces exhaustion resistance

CAR T cells mediate antitumor effects in a small subset of cancer patients(1–3), but dysfunction due to T cell exhaustion is an important barrier to progress(4–6). To investigate the biology of exhaustion in human T cells expressing CAR receptors, we used a model system employing a tonically signali...

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Publicado en:Nature
Main Authors: Lynn, Rachel C., Weber, Evan W., Sotillo, Elena, Gennert, David, Xu, Peng, Good, Zinaida, Anbunathan, Hima, Lattin, John, Jones, Robert, Tieu, Victor, Nagaraja, Surya, Granja, Jeffrey, DeBourcy, Charles, Majzner, Robbie, Satpathy, Ansuman T., Quake, Stephen R., Monje, Michelle, Chang, Howard, Mackall, Crystal L.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944329/
https://ncbi.nlm.nih.gov/pubmed/31802004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1805-z
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