Are the Hydantoin-1,3,5-triazine 5-HT(6)R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro

Though the 5-HT(6) serotonin receptor is an important target giving both agonists and antagonists similar therapeutic potency in the treatment of topic CNS-diseases, no 5-HT(6)R ligand has reached the pharmaceutical market yet due to the too narrow chemical space of the known 5-HT(6)R agents and ins...

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Udgivet i:Molecules
Main Authors: Lubelska, Annamaria, Latacz, Gniewomir, Jastrzębska-Więsek, Magdalena, Kotańska, Magdalena, Kurczab, Rafał, Partyka, Anna, Marć, Małgorzata Anna, Wilczyńska, Daria, Doroz-Płonka, Agata, Łażewska, Dorota, Wesołowska, Anna, Kieć-Kononowicz, Katarzyna, Handzlik, Jadwiga
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943527/
https://ncbi.nlm.nih.gov/pubmed/31817628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244472
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