Study on the effect of EMD386088, a 5-HT(6) receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats

The effect of some antidepressants co-administered with EMD386088 in the modified forced swim test in rats was investigated. Additionally, the pharmacokinetics, metabolic stability, and the effect of EMD386088 on P450 cytochromes were determined. Intraperitoneal (i.p.) coadministration of EMD386088...

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Détails bibliographiques
Publié dans:Naunyn Schmiedebergs Arch Pharmacol
Auteurs principaux: Jastrzębska-Więsek, Magdalena, Siwek, Agata, Partyka, Anna, Kołaczkowski, Marcin, Walczak, Maria, Smolik, Magdalena, Latacz, Gniewomir, Kieć-Kononowicz, Katarzyna, Wesołowska, Anna
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2017
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748433/
https://ncbi.nlm.nih.gov/pubmed/29079874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-017-1431-y
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