Study on the effect of EMD386088, a 5-HT(6) receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats

The effect of some antidepressants co-administered with EMD386088 in the modified forced swim test in rats was investigated. Additionally, the pharmacokinetics, metabolic stability, and the effect of EMD386088 on P450 cytochromes were determined. Intraperitoneal (i.p.) coadministration of EMD386088...

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Bibliografiske detaljer
Udgivet i:Naunyn Schmiedebergs Arch Pharmacol
Main Authors: Jastrzębska-Więsek, Magdalena, Siwek, Agata, Partyka, Anna, Kołaczkowski, Marcin, Walczak, Maria, Smolik, Magdalena, Latacz, Gniewomir, Kieć-Kononowicz, Katarzyna, Wesołowska, Anna
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2017
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748433/
https://ncbi.nlm.nih.gov/pubmed/29079874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-017-1431-y
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