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The role of aryl-topology in balancing between selective and dual 5-HT(7)R/5-HT(1A) actions of 3,5-substituted hydantoins
In order to search for active and selective serotonin 5-HT(7)R antagonists among 3,5-disubstituted arylpiperazine-imidazolidine-2,4-diones, the role of the introduction/deletion and the mutual orientation of aromatic rings was analyzed. Chemical modifications of 2nd generation lead structure of 3-(3...
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| Wydane w: | Medchemcomm |
|---|---|
| Główni autorzy: | , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Royal Society of Chemistry
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6072329/ https://ncbi.nlm.nih.gov/pubmed/30108992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00168e |
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