The role of aryl-topology in balancing between selective and dual 5-HT(7)R/5-HT(1A) actions of 3,5-substituted hydantoins

In order to search for active and selective serotonin 5-HT(7)R antagonists among 3,5-disubstituted arylpiperazine-imidazolidine-2,4-diones, the role of the introduction/deletion and the mutual orientation of aromatic rings was analyzed. Chemical modifications of 2nd generation lead structure of 3-(3...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Kucwaj-Brysz, Katarzyna, Kurczab, Rafał, Żesławska, Ewa, Lubelska, Annamaria, Marć, Małgorzata Anna, Latacz, Gniewomir, Satała, Grzegorz, Nitek, Wojciech, Kieć-Kononowicz, Katarzyna, Handzlik, Jadwiga
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072329/
https://ncbi.nlm.nih.gov/pubmed/30108992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00168e
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