Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT(7) receptor agonists

Close structural analogues of 5-carboxamidotryptamine (5-CT) based on the newly discovered indole–imidazole scaffold were synthesized and evaluated to search for a 5-HT(7) receptor agonist of higher selectivity. In vitro drug-likeness studies and in vivo pharmacological evaluation of potent and sele...

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Опубликовано в: :Medchemcomm
Главные авторы: Latacz, Gniewomir, Hogendorf, Adam S., Hogendorf, Agata, Lubelska, Annamaria, Wierońska, Joanna M., Woźniak, Monika, Cieślik, Paulina, Kieć-Kononowicz, Katarzyna, Handzlik, Jadwiga, Bojarski, Andrzej J.
Формат: Artigo
Язык:Inglês
Опубликовано: Royal Society of Chemistry 2018
Предметы:
Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256855/
https://ncbi.nlm.nih.gov/pubmed/30568756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00313k
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