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Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT(7) receptor agonists
Close structural analogues of 5-carboxamidotryptamine (5-CT) based on the newly discovered indole–imidazole scaffold were synthesized and evaluated to search for a 5-HT(7) receptor agonist of higher selectivity. In vitro drug-likeness studies and in vivo pharmacological evaluation of potent and sele...
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| Τόπος έκδοσης: | Medchemcomm |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Royal Society of Chemistry
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6256855/ https://ncbi.nlm.nih.gov/pubmed/30568756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00313k |
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