Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats

A newly developed series of non-imidazole histamine H3 receptor (H3R) antagonists (1–16) was evaluated in vivo for anticonvulsant effects in three different seizure models in Wistar rats. Among the novel H3R antagonists examined, H3R antagonist 4 shortened the duration of tonic hind limb extension (...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Alachkar, Alaa, Łażewska, Dorota, Latacz, Gniewomir, Frank, Annika, Siwek, Agata, Lubelska, Annamaria, Honkisz-Orzechowska, Ewelina, Handzlik, Jadwiga, Stark, Holger, Kieć-Kononowicz, Katarzyna, Sadek, Bassem
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274786/
https://ncbi.nlm.nih.gov/pubmed/30380674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113386
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