Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats

BACKGROUND: Alzheimer disease (AD) is the main cause of dementia in elderly people. The potential of histamine H3 receptor (H3R) antagonists as a pharmacological treatment of several neuropsychiatric diseases is well established. METHODS: The novel non-imidazole-based H3R antagonist E177 was screene...

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Vydáno v:Neuropsychiatr Dis Treat
Hlavní autoři: Alachkar, Alaa, Khan, Nadia, Łażewska, Dorota, Kieć-Kononowicz, Katarzyna, Sadek, Bassem
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6388968/
https://ncbi.nlm.nih.gov/pubmed/30863075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/NDT.S193125
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