In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages

The introduction of non-bridging phosphorothioate (PS) linkages in oligonucleotides has been instrumental for the development of RNA therapeutics and antisense oligonucleotides. This modification offers significantly increased metabolic stability as well as improved pharmacokinetic properties. Howev...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Duschmalé, Jörg, Hansen, Henrik Frydenlund, Duschmalé, Martina, Koller, Erich, Albaek, Nanna, Møller, Marianne Ravn, Jensen, Klaus, Koch, Troels, Wengel, Jesper, Bleicher, Konrad
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Chemical Biology and Nucleic Acid Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943131/
https://ncbi.nlm.nih.gov/pubmed/31754711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1099
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi